Apotransferrin protects cortical neurons from hemoglobin toxicity
نویسندگان
چکیده
منابع مشابه
Apotransferrin protects cortical neurons from hemoglobin toxicity.
The protective effect of iron chelators in experimental models of intracerebral hemorrhage suggests that nonheme iron may contribute to injury to perihematomal cells. Therapy with high affinity iron chelators is limited by their toxicity, which may be due in part to sequestration of metals in an inaccessible complex. Transferrin is unique in chelating iron with very high affinity while deliveri...
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BACKGROUND AND PURPOSE Hypoxia preconditioning (HPC), rapid or delayed, has been reported to induce neuroprotection against subsequent severe stress. Because delta-opioid receptor (DOR) plays an important role in delayed HPC-induced neuroprotection against severe hypoxic injury, we asked whether DOR is also involved in the rapid HPC-induced neuroprotection. METHODS Cultured rat cortical neuro...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2011
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2010.10.015